abstract：:The main purpose of this manuscript is to describe a phenomenon in which vacuum degassing a reconstituted freeze-dried fusion protein etanercept formulation caused a significant amount of protein sub-visible particles (SbVP). Physical stability of etanercept was monitored by micro-flow imaging (MFI), dynamic light sca...

journal_title：International journal of biological macromolecules

authors： Wang H,Zheng HJ,Wang Z,Bai H,Carpenter JF,Chen S,Fang WJ

更新日期：2014-05-01 00:00:00

abstract：:A new oxovanadium complex [VO(sal-l-val)(phen)] (sal-l-val=Schiff base derived from salicylaldehyde and l-valine; phen=1,10-phenanthroline) has been designed and synthesized with the aim of developing potential DNA nuclease. The interaction of DNA with this structurally characterized oxovanadium complex has been studi...

journal_title：International journal of biological macromolecules

authors： Saha U,Mukherjea KK

更新日期：2014-05-01 00:00:00

abstract：:Glycerol is an effective carbon source for the production of scl- and mcl-polyhydroxyalkanoates (PHAs) by Pseudomonas spp. P. mediterranea 9.1 (CFBP 5447) synthesizes an amorphous mcl-PHA when grown on crude glycerol, whereas on both reagent grade (RG) and partially refined (PR) glycerol, it produces two very similar ...

journal_title：International journal of biological macromolecules

authors： Pappalardo F,Fragalà M,Mineo PG,Damigella A,Catara AF,Palmeri R,Rescifina A

更新日期：2014-04-01 00:00:00

abstract：:Hot water extraction technique was employed to extract the hydrocolloid from Cordia myxa leaf (PCM). The optimal conditions for extraction of PCM were determined using response surface methodology. A Box-Behnken design (BBD) was applied to evaluate the effects of three independent variables (extraction time (X1: 1-4 h...

journal_title：International journal of biological macromolecules

authors： Samavati V,Lorestani M,Joolazadeh S

更新日期：2014-04-01 00:00:00

abstract：:In this study the extraction of hot water soluble polysaccharides (HWSPs) from Cymbopogon citratus using hot water decoction was discussed. Response surface methodology (RSM) based on a three level, three variable central composite rotatable design (CCRD), was employed to obtain best possible combination of extraction...

journal_title：International journal of biological macromolecules

authors： Thangam R,Suresh V,Kannan S

更新日期：2014-04-01 00:00:00

abstract：:To explore new antioxidant resource from food, a water-soluble polysaccharide (ALP1) was extracted and purified from the roots of Arctium lappa L. (A. lappa L.) through hot water extraction followed by ethanol precipitation, ion-exchange chromatography and gel filtration. The antioxidant activity of ALP1 was then eval...

journal_title：International journal of biological macromolecules

authors： Liu W,Wang J,Zhang Z,Xu J,Xie Z,Slavin M,Gao X

更新日期：2014-04-01 00:00:00

abstract：:Tyrosinase inhibitors have potential applications in the cosmetics and food industries for preventing browning reactions and also as therapeutic drugs for neurodegenerative diseases such as Parkinson's. In this article, crocin and curcumin were evaluated as mushroom tyrosinase inhibitors. Results showed that, both com...

journal_title：International journal of biological macromolecules

authors： Patil S,Srinivas S,Jadhav J

更新日期：2014-04-01 00:00:00

abstract：:Carbon tetrachloride (CCl4) is a potent hepatotoxic agent causing hepatic necrosis and it is widely used in animal models for induction of acute and chronic liver damage. The antioxidative and hepatoprotective effects of chitosan from Sepia kobiensis against CCl4 induced liver toxicity in Wistar rats was studied by me...

journal_title：International journal of biological macromolecules

authors： Ramasamy P,Subhapradha N,Shanmugam V,Shanmugam A

更新日期：2014-04-01 00:00:00

abstract：:The eggs of black widow spider (L. tredecimguttatus) have been demonstrated to be rich in biologically active components that exhibit great research value and application foreground. In the present study, a protein toxin, named Latroeggtoxin-II, was isolated from the eggs using the combination of gel filtration, ion e...

journal_title：International journal of biological macromolecules

authors： Li J,Yan Y,Yu H,Peng X,Zhang Y,Hu W,Duan Z,Wang X,Liang S

更新日期：2014-04-01 00:00:00

abstract：:Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage. In this study, the experimental data indicate that the presence of Tyr and Glu significantly suppress the metHb formation i...

journal_title：International journal of biological macromolecules

authors： Wei Y,Li C,Zhang L,Su Z,Xu X

更新日期：2014-03-01 00:00:00

abstract：:β-Lactoglobulin (β-LG) is the major constituent of whey food, which has been shown to interact with a wide range of aroma compounds. In the present work, a model aroma compound, β-ionone, is used to investigate the influence of aroma compounds on the urea-induced unfolding of β-LG at pH 7.0. β-Ionone is observed to en...

journal_title：International journal of biological macromolecules

authors： Ma B,You X,Lu F

更新日期：2014-03-01 00:00:00

abstract：:A polymer-mineral composite membrane of the mucopolysaccharide derivative, chitosan, and calcium silicate hydrate phase, tobermorite, was prepared by solvent casting and characterised by scanning electron microscopy (SEM) and Fourier Transform infrared spectroscopy (FTIR). The bioactivity and biocompatibility of the c...

journal_title：International journal of biological macromolecules

authors： Hurt AP,Getti G,Coleman NJ

更新日期：2014-03-01 00:00:00

abstract：:α-Glucosidase is a critical associated enzyme with type 2 diabetes mellitus in humans. Inhibition of α-glucosidase is important due to the potential effect of down regulating glucose absorption in patients. In this study, the inhibitory activity of flavone luteolin on α-glucosidase and their interaction mechanism were...

journal_title：International journal of biological macromolecules

authors： Yan J,Zhang G,Pan J,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:A series of adipic acid dihydrazide (ADH)-modified hyaluronic acid (HA-ADH) compounds were synthesized and conjugated with QDots (QDots-HA conjugates) to assess the effects of the molecular weight (MW) and extent of chemical modification of HA on its biodistribution. Their physicochemical structures were confirmed by ...

journal_title：International journal of biological macromolecules

authors： Hsieh CM,Huang YW,Sheu MT,Ho HO

更新日期：2014-03-01 00:00:00

abstract：:A terpolymer of chitosan-melamine-glutaraldehyde was prepared for the first time and it was quaternized with glycidyl trimethyl ammonium chloride (GTMAC). The quaternized chitosan-melamine-glutaraldehyde resin (QCMGR) was found to be effective for the removal of nitrate and phosphate oxyanions. The resin was character...

journal_title：International journal of biological macromolecules

authors： Sowmya A,Meenakshi S

更新日期：2014-03-01 00:00:00

abstract：:Microalgae have recently been recognized as a valuable resource for various applications. Phaeodactylum tricornutum is a diatom that lives in marine water and has an unusually high content of lipids. In this study, we added P. tricornutum into a gelatin dope solution to examine the effect of this diatom using electros...

journal_title：International journal of biological macromolecules

authors： Kwak HW,Kang MJ,Bae JH,Hur SB,Kim IS,Park YH,Lee KH

更新日期：2014-02-01 00:00:00

abstract：:Three novel thiosemicarbazone O-carboxymethyl chitosan derivatives were obtained via a condensation reaction of thiosemicarbazide O-carboxymethyl chitosan with o-hydroxybenzaldehyde, p-methoxybenzaldehyde, and p- chlorobenzaldehyde respectively. Their structures were characterized by elemental analysis, FTIR, (13)C NM...

journal_title：International journal of biological macromolecules

authors： Mohamed NA,Mohamed RR,Seoudi RS

更新日期：2014-02-01 00:00:00

abstract：:A series of hydroxy- and methoxy-substituted paeonol thiosemicarbazone analogues were synthesized as potential tyrosinase inhibitors and their inhibitory effects on mushroom tyrosinase and inhibitory mechanism were evaluated. Paeonol thiosemicarbazone analogues have been found exhibiting more remarkable inhibition tha...

journal_title：International journal of biological macromolecules

authors： Zhu TH,Cao SW,Yu YY

更新日期：2013-11-01 00:00:00

abstract：:Electrospinning technique was used to fabricate chloroamphenicol loaded poly (L-lactic acid)/ZrO2 (CP-PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PLLA/ZrO2 nanofibers increased with ZrO2 concentration increasing and ribbon-shape fibers were present when ZrO2 content reached 3% and above. The...

journal_title：International journal of biological macromolecules

authors： Wang H,Ma X,Li Y,Jiang S,Zhai L,Jiang S,Li X

更新日期：2013-11-01 00:00:00

abstract：:Recently, increasing evidences have suggested that inflammatory stress is markedly occurred in the impaired tissue. Thus, the streptozotocin (STZ)-induced diabetic mice were used to investigate the potential renoprotective effect of ramulus mori polysaccharides (RMP) and to discuss the underlying mechanism. The result...

journal_title：International journal of biological macromolecules

authors： Guo C,Liang T,He Q,Wei P,Zheng N,Xu L

更新日期：2013-11-01 00:00:00

abstract：:Structural changes in R-phycoerythrin used as a matrix for the synthesis of CdS quantum dots have been analyzed by circular dichroism spectrometry. In deionized water, quantum dot synthesis in the tunnel cavity of the R-phycoerythrin molecule proved to be accompanied by uncoiling of α-helices and changes in the confor...

journal_title：International journal of biological macromolecules

authors： Bekasova OD,Shubin VV,Safenkova IV,Kovalyov LI,Kurganov BI

更新日期：2013-11-01 00:00:00

abstract：:The present study was performed to investigate the chemical composition and antioxidant activity of glycoprotein purified from Undaria pinnatifida Harvey (UPGP). On SDS-PAGE, UPGP migrated as a single band with a molecular weight of approximately 10 kDa and confirmed by staining with Schiff's reagent as glycoprotein. ...

journal_title：International journal of biological macromolecules

authors： Rafiquzzaman SM,Kim EY,Kim YR,Nam TJ,Kong IS

更新日期：2013-11-01 00:00:00

abstract：:Chitooligosaccharides (COS) display a variety of important biological activities, including antimicrobial, antitumor, anti-inflammatory, and immunoenhancing. In the present study, a COS sample (degree of polymerization 4-11, analyzed by FTIR and MALDI-TOF-MS) prepared by hydrolysis with a recombinant chitosanase was o...

journal_title：International journal of biological macromolecules

authors： Mei YX,Chen HX,Zhang J,Zhang XD,Liang YX

更新日期：2013-11-01 00:00:00

abstract：:In this study, an oxidative stress model was first developed in a mouse macrophage cell line (RAW264.7 cells) by infecting the cells with porcine circovirus type 2 (PCV2). The regulatory effect of Sophora subprosrate polysaccharide (SSP) on PCV2-induced oxidative stress was investigated. The results showed that after ...

journal_title：International journal of biological macromolecules

authors： Su ZJ,Wei YY,Yin D,Shuai XH,Zeng Y,Hu TJ

更新日期：2013-11-01 00:00:00

abstract：:Recently, much attention has been paid by consumers toward natural bioactive compounds as functional ingredients in nutraceuticals. Marine algae are considered as valuable sources of structurally diverse bioactive compounds. Marine algae are rich in sulfated polysaccharides (SPs) such as carrageenans in red algae, fuc...

journal_title：International journal of biological macromolecules

authors： Ngo DH,Kim SK

更新日期：2013-11-01 00:00:00

abstract：:Various materials, both biological and alloplastic, have been used for mastoid obliteration after canal wall-down mastoidectomy in chronic otitis media. The purpose of this study is to investigate the osteoinductive potential of PCL scaffolds in mastoid obliteration, and to test that osteoinductivity can be enhanced b...

journal_title：International journal of biological macromolecules

authors： Jang CH,Kim MS,Cho YB,Jang YS,Kim GH

更新日期：2013-11-01 00:00:00

abstract：:Guar gum, being the natural polymer is renewable, nontoxic, biocompatible and biodegradable. Therefore, it is the perfect material to formulate particulates or microspheres for potential applications in pharmaceutical. The formulation of material in nano/microsphere scale offers new rich in application potential. In v...

journal_title：International journal of biological macromolecules

authors： Sharma S,Kaur J,Sharma G,Thakur KK,Chauhan GS,Chauhan K

更新日期：2013-11-01 00:00:00

abstract：:Microbial and plant polysaccharides in nature are frequently exposed to oxidative burst. They may act as antioxidants buffering the radical attack. This paper presents antioxidant properties of prepared yeast mannans, commercial β-glucans as well as the chemically prepared carboxymethylated β-glucan (CM-glucan). The h...

journal_title：International journal of biological macromolecules

authors： Machová E,Bystrický S

更新日期：2013-10-01 00:00:00

abstract：:Gamma radiation was used as the initiator/crosslinker agent for the synthesis of thermo-sensitive hydrogel networks, under the form of membranes, using dextran and N-isopropylacrylamide. The prepared membranes were loaded with Ondansetron™, a potent antiemetic drug and tested as drug delivery systems. The characteriza...

journal_title：International journal of biological macromolecules

authors： Almeida JF,Ferreira P,Alves P,Lopes A,Gil MH

更新日期：2013-10-01 00:00:00

abstract：:This work aimed to study the potential of 155 strains of Bacillus sp., isolated from a collection of Tunisian microorganisms, for polyhydroxyalcanoates production. The strains were submitted to a battery of standard tests commonly used for determining bioplastic properties. The findings revealed that two of the isolat...

journal_title：International journal of biological macromolecules

authors： Zribi-Maaloul E,Trabelsi I,Elleuch L,Chouayekh H,Ben Salah R

更新日期：2013-10-01 00:00:00

abstract：:The endogenous deposition of protein aggregates with fibrillar morphology is known to govern the genesis of several neurodisorders. The investigation of naturally occurring small molecules which can restrict the fibrillation process can help in the design of rational therapeutics for neurodegenerative diseases. We rep...

journal_title：International journal of biological macromolecules

authors： Pandey NK,Ghosh S,Dasgupta S

更新日期：2013-10-01 00:00:00

abstract：:We explored a method to examine the hydrolysis of isoflavone glycoside by immobilizing β-glucosidase on chitosan-carbon beads in an aqueous-organic two-phase system. The chitosan-carbon beads were cross-linked with glutaraldehyde to immobilize β-glucosidase from Exiguobacterium sp. DAU5. The optimal pH and temperature...

journal_title：International journal of biological macromolecules

authors： Chang J,Lee YS,Fang SJ,Park DJ,Choi YL

更新日期：2013-10-01 00:00:00

abstract：:The aim of this study was to investigate the inhibitory effects of molecular weight alteration of Dendrobium huoshanense polysaccharide on protein nonenzymatic glycation. For this purpose, one homogeneous active polysaccharide DHPD1 with molecular weight 3.2 kDa was extracted from D. huoshanense. GC analysis showed th...

journal_title：International journal of biological macromolecules

authors： Zha XQ,Li XL,Zhang HL,Cui SH,Liu J,Wang JH,Pan LH,Luo JP

更新日期：2013-10-01 00:00:00

abstract：:Peanut allergy is IgE-mediated type-I hypersensitivity, and T helper 2 cytokines are central to those pathogenesis. We investigated the effects of the administration of chitin and chitosan on peanut-induced hypersensitivities in mouse food allergy models. Chitin and chitosan protected mice against peanut-induced anaph...

journal_title：International journal of biological macromolecules

authors： Bae MJ,Shin HS,Kim EK,Kim J,Shon DH

更新日期：2013-10-01 00:00:00

abstract：:Three phase partitioning is a process in which mixing t-butanol with ammonium sulphate with a protein solution leads to the formation of three phases. Generally, the interfacial protein precipitate (formed between upper t-butanol rich and lower aqueous phase) can be easily dissolved back in aqueous buffers. In case of...

journal_title：International journal of biological macromolecules

authors： Rather GM,Gupta MN

更新日期：2013-09-01 00:00:00

abstract：:Four water-soluble polysaccharides (LSPa1, LSPb1, LSPb2 and LSPc1) extracted from the fruiting bodies of Lepista sordida were prepared by DEAE cellulose-52 anion-exchange and Sepharose 6 Fast Flow gel-permeation chromatography. LSPa1 was composed of Glc, Man and Gal with a molar ratio of 3.2: 1.3: 0.6. LSPb1, LSPb2 an...

journal_title：International journal of biological macromolecules

authors： Miao S,Mao X,Pei R,Miao S,Xiang C,Lv Y,Yang X,Sun J,Jia S,Liu Y

更新日期：2013-09-01 00:00:00

abstract：:Conjugation of various arginine-rich peptide sequences to vectors based on 10 kDa polyethylenimine (PEI) and its hydrophobic derivative (hexanoate-PEI) was investigated as a strategy for improving pDNA and siRNA transfection activities. Six different arginine-histidine (RH) sequences and two arginine-serine (RS) seque...

journal_title：International journal of biological macromolecules

authors： Parhiz H,Hashemi M,Hatefi A,Shier WT,Amel Farzad S,Ramezani M

更新日期：2013-09-01 00:00:00

abstract：:Mechanistic understanding of interaction of drugs with their target molecule is important for development of new drug therapy regimes. Idarubicin (IDR) is a potent chemotherapeutic agent used to treat variety of cancers. Structural and conformational studies associated with binding of IDR on DNA double helix were inve...

journal_title：International journal of biological macromolecules

authors： Charak S,Mehrotra R

更新日期：2013-09-01 00:00:00

abstract：:Chemical modification of dietary fiber (DF), extracted from whole grain barley, was carried out to obtain cross-linked (CL) DF, carboxymethyl (CM) DF, and hydroxypropyl (HP) DF. The DF components, physicochemical properties, and subsequent influence on the in vitro digestibility of wheat starch gels were comparatively...

journal_title：International journal of biological macromolecules

authors： Park KH,Lee KY,Lee HG

更新日期：2013-09-01 00:00:00

abstract：:Doogh is a fermented dairy drink which is highly consumed by Iranian people. Stability of this healthy drink was investigated in terms of sedimentation rate, viscosity, density and particle size characteristics including surface-weighted mean diameter (D32), Span and particle uniformity. Eight treatments were performe...

journal_title：International journal of biological macromolecules

authors： Joudaki H,Mousavi M,Safari M,Razavi SH,Emam-Djomeh Z,Gharibzahedi SM

更新日期：2013-09-01 00:00:00